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KMID : 0357920070410050358
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Korean Journal of Pathology
2007 Volume.41 No. 5 p.358 ~ p.361
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Progressive Multifocal Leukoencephalopathy in the Immunocompromised Patients- 3 Cases Report -
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Shim Min-Keun
Choi Yoo-Duk
Park Chang-Soo
Lee Min-Cheol
Kim Hyung-Seok
Kim Jo-Heon
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Abstract
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Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease resulting from infection of oligodendrocytes with JC virus. PML was a rare disease, but nowadays not uncommon as AIDS prevailed. Histopathologic features of the affected lesion shows infiltrations of foamy macrophages and hyperchromatic, pleomorphic, reactive astrocytes that may raise the suspicion of a brain tumor. We recently met with 3 cases of PML. Two of the patients had AIDS and the other had been treated for lymphoma. All cases were diagnosed by histopathologic examination in stereotactic brain biopsies.
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KEYWORD
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Leukoencephalopathy, progressive multifocal, JC virus, Acquired immunodeficiency syndrome, Lymphoma, Biopsy
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